Dapsone is a prescription antibiotic used mainly for certain skin conditions and some infections. If your doctor suggested dapsone, you probably want to know how it works, what to watch for, and how to use it safely. This guide gives clear, practical answers so you can talk with your prescriber.
Dapsone treats dermatitis herpetiformis (a blistering skin disease), some types of acne, and is a core drug for leprosy. It also appears in combination regimens for certain resistant infections. You’ll see two main forms: oral tablets and topical gel. Oral doses commonly range from 50 mg to 100 mg once daily for skin diseases; leprosy regimens use different schedules supervised by specialists. Topical dapsone gel is used for acne and has fewer systemic effects.
Getting a prescription and buying safely
Dapsone requires a prescription in most countries. Ask your clinician why it’s recommended, expected benefits, and how long you’ll need it. Avoid pharmacies that don’t ask for a prescription — that’s risky. If you buy online, use verified pharmacies with pharmacists you can contact and clear return policies. Keep the medication in its original packaging and store it away from heat and moisture.
Before starting dapsone your provider should check for G6PD deficiency. Dapsone can cause hemolytic anemia in people with low G6PD. Expect a baseline complete blood count (CBC) and periodic CBC checks during treatment, especially the first few months. Also report any unusual tiredness, dark urine, rapid heart rate, or shortness of breath right away.
Methemoglobinemia is a less common but serious side effect. Symptoms include grayish skin, shortness of breath, or bluish lips. If you notice these, seek urgent care. Liver tests may be ordered if you have liver disease or take other liver-impacting drugs.
Common side effects and interactions
Mild side effects include nausea, headache, and skin irritation with topical use. Avoid combining dapsone with other drugs that raise methemoglobin or strongly oxidize red blood cells, such as high-dose nitrites or certain antibiotics and sulfonamides, unless your doctor manages it. Tell your prescriber about all medications, supplements, and herbal products you take.
Pregnancy, breastfeeding, and children
Dapsone can pass into breast milk and crosses the placenta. Use in pregnancy or breastfeeding should only happen if benefits outweigh risks and under close medical supervision. Pediatric dosing varies; a specialist should handle treatment for children.
Practical tips for patients
Take oral dapsone with food to lower stomach upset. Don’t stop suddenly without talking to your provider—some conditions can flare. Keep follow-up appointments for blood tests, and carry a note about G6PD status if you have it. If you experience severe side effects, stop the drug and seek medical help.
Ask questions. A short conversation with your prescriber and pharmacist makes dapsone safer and more effective.
If you have concerns about side effects or interactions, write them down before appointments. Bring a current medication list. If you travel, keep a supply and prescriptions handy in original packaging and contact numbers for emergencies.
