Quick fact: sucralfate doesn't neutralize stomach acid — it sticks to an ulcer and forms a protective barrier so the tissue can heal. That makes it different from antacids and proton pump inhibitors (PPIs). If you want relief that protects the raw spot in your stomach or esophagus, sucralfate is the tool doctors often pick.
Sucralfate is a powder or tablet that turns into a paste when it meets stomach acid. That paste coats ulcers and irritated areas, keeping acid and enzymes off the sore tissue. Doctors commonly prescribe it for active duodenal ulcers, some cases of gastritis, and reflux-related esophagitis. It can also be used to protect the lining after certain procedures or radiation therapy when directed by a specialist.
Important note: sucralfate is not a treatment for H. pylori infection and won't replace antibiotics or standard ulcer combinations when H. pylori is the cause.
Typical adult dosing is 1 gram by mouth four times a day — usually one hour before meals and again at bedtime. A 2-gram twice-daily regimen is sometimes used, but always follow your prescriber's instructions. The liquid form can coat better for severe esophagitis; shake it well and measure accurately.
Timing matters: sucralfate can bind other medicines and stop them working. Take other oral meds at least two hours before or after sucralfate. That includes antibiotics like doxycycline and fluoroquinolones, thyroid pills, phenytoin, digoxin, and warfarin. Antacids can also interfere, so space them out.
Watch kidney health: sucralfate contains aluminum. People with poor kidney function can accumulate aluminum and should use sucralfate with caution — talk to your doctor or pharmacist first. Common side effects are mild: constipation is the most frequent. You might also feel dry mouth, nausea, or an upset stomach.
When to call your doctor: if you notice black or bloody stools, vomit that looks like coffee grounds, sudden severe belly pain, or new/worsening heartburn or difficulty swallowing. These could be signs of bleeding or a complication that needs urgent care.
Simple tips that help: take sucralfate on an empty stomach (about one hour before meals), keep a two-hour gap from other pills, and finish the full course even if you feel better. Store tablets and suspension at room temperature and keep them away from kids and pets.
If you're pregnant, breastfeeding, or have chronic kidney disease, mention this before starting sucralfate. Your provider will weigh benefits and risks and may adjust dosing or suggest alternatives. If you want a quick recap: sucralfate protects ulcers by coating them, needs careful timing with other meds, and is usually safe — but watch for constipation and talk to your doctor if you have kidney trouble.
