Tretinoin: what it does and how to use it safely
Tretinoin is a topical retinoid most people use for acne and sun-damaged skin. It speeds up cell turnover, helps clear clogged pores, and can soften fine lines and dark spots over time. It’s powerful, so you’ll get results—but you’ll also need patience and a simple routine to avoid irritation.
How to use tretinoin safely
Start slow. Apply a pea-sized amount at night to clean, dry skin—wait 20–30 minutes after washing your face if your skin is wet. Begin every other night for the first 2–4 weeks, then move to nightly if your skin tolerates it. Use only a thin layer; more doesn’t mean faster results and often causes more redness and peeling.
Common prescription strengths are 0.025%, 0.05%, and 0.1%. If you’re new to retinoids, choose a lower strength first or ask your clinician. Pair tretinoin with a gentle moisturizer—apply moisturizer after tretinoin or use the ‘‘sandwich’’ method (moisturizer, tretinoin, then another light moisturizer) if your skin gets very dry.
Sun protection is non-negotiable. Tretinoin increases sun sensitivity, so use broad-spectrum sunscreen (SPF 30+) every morning and wear a hat on bright days.
What to expect and common side effects
Expect redness, flaking, and mild burning early on—this is called retinization and usually eases after 4–12 weeks. Acne improvement often shows at 8–12 weeks; texture and pigmentation changes can take 3–6 months. If you get intense irritation (open sores, severe swelling), stop use and contact your prescriber.
Avoid combining tretinoin with other strong actives without guidance: benzoyl peroxide, salicylic acid, alpha hydroxy acids, and prescription retinoids can increase irritation. Don’t wax facial hair while using tretinoin and skip aggressive chemical peels until your skin has recovered.
Pregnancy and breastfeeding: topical tretinoin is usually not recommended during pregnancy. Talk to your doctor if you’re pregnant, planning pregnancy, or breastfeeding before starting tretinoin.
Buying and storing tretinoin — quick tips: get it from a licensed pharmacy with a valid prescription. Beware of suspiciously cheap online sellers; counterfeit products are common. Store tretinoin at room temperature, away from direct light and heat, and keep the tube or pump tightly closed.
Want more practical articles? We have guides on acne treatments, safe online pharmacies, and ingredient comparisons to help you pick the right option. If you’re unsure which strength or routine fits you, a short visit with a dermatologist will save time and avoid problems.
